dr Paweł Zawadzki

Zhang, Qian; Bastard, Paul; Liu, Zhiyong; é, Jér; Moncada-Velez, Marcela; Chen, Jie; Ogishi, Masato; Sabli, Ira K D; Hodeib, Stephanie; Korol, Cecilia; Rosain, Jeremie; Bilguvar, Kaya; Ye, Junqiang; Bolze, Alexandre; Bigio, Benedetta; Yang, Rui; Arias, Andres Augusto; Zhou, Qinhua; Zhang, Yu; Onodi, Fanny; Korniotis, Sarantis; Karpf, Lea; Philippot, Quentin; Chbihi, Marwa; Bonnet-Madin, Lucie; Dorgham, Karim; Smith, Nikaïa; Schneider, William M; Razooky, Brandon S; Hoffmann, Hans-Heinrich; Michailidis, Eleftherios; Moens, Leen; Han, Ji Eun; Lorenzo, Lazaro; Bizien, Lucy; Meade, Philip; Neehus, Anna-Lena; Ugurbil, Aileen Camille; é, Aur; Kerner, Gaspard; Zhang, Peng; Rapaport, Franck; Seeleuthner, Yoann; Manry, Jeremy; Masson, Cecile; Schmitt, Yohann; Schlüter, Agatha; Voyer, Tom Le; Khan, Taushif; Li, Juan; Fellay, Jacques; Roussel, Lucie; Shahrooei, Mohammad; Alosaimi, Mohammed F; Mansouri, Davood; Al-Saud, Haya; Al-Mulla, Fahd; Almourfi, Feras; Al-Muhsen, Saleh Zaid; Alsohime, Fahad; Turki, Saeed Al; Hasanato, Rana; van de Beek, Diederik; Biondi, Andrea; Bettini, Laura Rachele; DÁngio', Mariella; Bonfanti, Paolo; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Oler, Andrew J; Tompkins, Miranda F; Alba, Camille; Vandernoot, Isabelle; Goffard, Jean-Christophe; Smits, Guillaume; Migeotte, Isabelle; Haerynck, Filomeen; Soler-Palacin, Pere; Martin-Nalda, Andrea; Colobran, Roger; Morange, Pierre-Emmanuel; Keles, Sevgi; Colkesen, Fatma; Ozcelik, Tayfun; Yasar, Kadriye Kart; Senoglu, Sevtap; Karabela, Semsi Nur; í, Carlos Rodr; Novelli, Giuseppe; Hraiech, Sami; Tandjaoui-Lambiotte, Yacine; Duval, Xavier; Laouenan, Cedric; Snow, Andrew L; Dalgard, Clifton L; Milner, Joshua D; Vinh, Donald C; Mogensen, Trine H; Marr, Nico; á, Andr; Boisson, Bertrand; Boisson-Dupuis, Stephanie; Bustamante, Jacinta; Puel, Anne; Ciancanelli, Michael J; Meyts, Isabelle; Maniatis, Tom; Soumelis, Vassili; Amara, Ali; Nussenzweig, Michel; Garcia-Sastre, Adolfo; Krammer, Florian; Pujol, Aurora; Duffy, Darragh; Lifton, Richard P; Zhang, Shen-Ying; Gorochov, Guy; Beziat, Vivien; Jouanguy, Emmanuelle; Sancho-Shimizu, Vanessa; Rice, Charles M; Abel, Laurent; Notarangelo, Luigi D; é, Aur; Su, Helen C; Casanova, Jean-Laurent; Zawadzki, Paweł; ...,

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Science, 370 (6515), pp. eabd4570, 2020.

Links - BibTeX - Tagi:

@article{Zhang2020,
title = {Inborn errors of type I IFN immunity in patients with life-threatening COVID-19},
author = {Qian Zhang and Paul Bastard and Zhiyong Liu and Jér é and Marcela Moncada-Velez and Jie Chen and Masato Ogishi and Ira K D Sabli and Stephanie Hodeib and Cecilia Korol and Jeremie Rosain and Kaya Bilguvar and Junqiang Ye and Alexandre Bolze and Benedetta Bigio and Rui Yang and Andres Augusto Arias and Qinhua Zhou and Yu Zhang and Fanny Onodi and Sarantis Korniotis and Lea Karpf and Quentin Philippot and Marwa Chbihi and Lucie Bonnet-Madin and Karim Dorgham and Nikaïa Smith and William M Schneider and Brandon S Razooky and Hans-Heinrich Hoffmann and Eleftherios Michailidis and Leen Moens and Ji Eun Han and Lazaro Lorenzo and Lucy Bizien and Philip Meade and Anna-Lena Neehus and Aileen Camille Ugurbil and Aur é and Gaspard Kerner and Peng Zhang and Franck Rapaport and Yoann Seeleuthner and Jeremy Manry and Cecile Masson and Yohann Schmitt and Agatha Schlüter and Tom Le Voyer and Taushif Khan and Juan Li and Jacques Fellay and Lucie Roussel and Mohammad Shahrooei and Mohammed F Alosaimi and Davood Mansouri and Haya Al-Saud and Fahd Al-Mulla and Feras Almourfi and Saleh Zaid Al-Muhsen and Fahad Alsohime and Saeed Al Turki and Rana Hasanato and Diederik van de Beek and Andrea Biondi and Laura Rachele Bettini and Mariella DÁngio' and Paolo Bonfanti and Luisa Imberti and Alessandra Sottini and Simone Paghera and Eugenia Quiros-Roldan and Camillo Rossi and Andrew J Oler and Miranda F Tompkins and Camille Alba and Isabelle Vandernoot and Jean-Christophe Goffard and Guillaume Smits and Isabelle Migeotte and Filomeen Haerynck and Pere Soler-Palacin and Andrea Martin-Nalda and Roger Colobran and Pierre-Emmanuel Morange and Sevgi Keles and Fatma Colkesen and Tayfun Ozcelik and Kadriye Kart Yasar and Sevtap Senoglu and Semsi Nur Karabela and Carlos Rodr í and Giuseppe Novelli and Sami Hraiech and Yacine Tandjaoui-Lambiotte and Xavier Duval and Cedric Laouenan and Andrew L Snow and Clifton L Dalgard and Joshua D Milner and Donald C Vinh and Trine H Mogensen and Nico Marr and Andr á and Bertrand Boisson and Stephanie Boisson-Dupuis and Jacinta Bustamante and Anne Puel and Michael J Ciancanelli and Isabelle Meyts and Tom Maniatis and Vassili Soumelis and Ali Amara and Michel Nussenzweig and Adolfo Garcia-Sastre and Florian Krammer and Aurora Pujol and Darragh Duffy and Richard P Lifton and Shen-Ying Zhang and Guy Gorochov and Vivien Beziat and Emmanuelle Jouanguy and Vanessa Sancho-Shimizu and Charles M Rice and Laurent Abel and Luigi D Notarangelo and Aur é and Helen C Su and Jean-Laurent Casanova and Paweł Zawadzki and ...},
url = {https://doi.org/10.1126/science.abd4570},
doi = {10.1126/science.abd4570},
year = {2020},
date = {2020-01-01},
journal = {Science},
volume = {370},
number = {6515},
pages = {eabd4570},
publisher = {American Association for the Advancement of Science (AAAS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Bastard, Paul; Rosen, Lindsey B; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémie; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; de Jesus, Adriana Almeida; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Pen, Jeremie Le; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; á, Andr; Delmonte, Ottavia M; Abers, Michael S; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; Lifton, Richard P; Vasse, Marc; Smadja, David M; é, M; é, J; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; Vinh, Donald C; Tangye, Stuart G; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; Nussenzweig, Michel C; é, St; í, Carlos Rodr; Vogt, Guillaume; Mogensen, Trine H; Oler, Andrew J; Gu, Jingwen; Burbelo, Peter D; Cohen, Jeffrey I; Biondi, Andrea; Bettini, Laura Rachele; textquotesingle, Mariella D; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; é, Fréd; Husebye, Eystein S; Fusco, Francesca; Ursini, Matilde Valeria; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Marseglia, Gian Luigi; Duval, Xavier; Ghosn, Jade; Tsang, John S; Goldbach-Mansky, Raphaela; Kisand, Kai; Lionakis, Michail S; Puel, Anne; Zhang, Shen-Ying; Holland, Steven M; Gorochov, Guy; Jouanguy, Emmanuelle; Rice, Charles M; é, Aur; Notarangelo, Luigi D; Abel, Laurent; Su, Helen C; Casanova, Jean-Laurent; Zawadzki, Paweł; ...,

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Science, 370 (6515), pp. eabd4585, 2020.

Links - BibTeX - Tagi:

@article{Bastard2020,
title = {Autoantibodies against type I IFNs in patients with life-threatening COVID-19},
author = {Paul Bastard and Lindsey B Rosen and Qian Zhang and Eleftherios Michailidis and Hans-Heinrich Hoffmann and Yu Zhang and Karim Dorgham and Quentin Philippot and Jérémie Rosain and Vivien Béziat and Jérémie Manry and Elana Shaw and Liis Haljasmägi and Pärt Peterson and Lazaro Lorenzo and Lucy Bizien and Sophie Trouillet-Assant and Kerry Dobbs and Adriana Almeida de Jesus and Alexandre Belot and Anne Kallaste and Emilie Catherinot and Yacine Tandjaoui-Lambiotte and Jeremie Le Pen and Gaspard Kerner and Benedetta Bigio and Yoann Seeleuthner and Rui Yang and Alexandre Bolze and Andr á and Ottavia M Delmonte and Michael S Abers and Alessandro Aiuti and Giorgio Casari and Vito Lampasona and Lorenzo Piemonti and Fabio Ciceri and Kaya Bilguvar and Richard P Lifton and Marc Vasse and David M Smadja and M é and J é and Benjamin Terrier and Darragh Duffy and Lluis Quintana-Murci and Diederik van de Beek and Lucie Roussel and Donald C Vinh and Stuart G Tangye and Filomeen Haerynck and David Dalmau and Javier Martinez-Picado and Petter Brodin and Michel C Nussenzweig and St é and Carlos Rodr í and Guillaume Vogt and Trine H Mogensen and Andrew J Oler and Jingwen Gu and Peter D Burbelo and Jeffrey I Cohen and Andrea Biondi and Laura Rachele Bettini and Mariella D textquotesingle and Paolo Bonfanti and Patrick Rossignol and Julien Mayaux and Fréd é and Eystein S Husebye and Francesca Fusco and Matilde Valeria Ursini and Luisa Imberti and Alessandra Sottini and Simone Paghera and Eugenia Quiros-Roldan and Camillo Rossi and Riccardo Castagnoli and Daniela Montagna and Amelia Licari and Gian Luigi Marseglia and Xavier Duval and Jade Ghosn and John S Tsang and Raphaela Goldbach-Mansky and Kai Kisand and Michail S Lionakis and Anne Puel and Shen-Ying Zhang and Steven M Holland and Guy Gorochov and Emmanuelle Jouanguy and Charles M Rice and Aur é and Luigi D Notarangelo and Laurent Abel and Helen C Su and Jean-Laurent Casanova and Paweł Zawadzki and ...},
url = {https://doi.org/10.1126/science.abd4585},
doi = {10.1126/science.abd4585},
year = {2020},
date = {2020-01-01},
journal = {Science},
volume = {370},
number = {6515},
pages = {eabd4585},
publisher = {American Association for the Advancement of Science (AAAS)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Sowińska-Seidler, Anna; Sztromwasser, Paweł; Zawadzka, Katarzyna; Sielski, Dawid; Bukowska-Olech, Ewelina; Zawadzki, Paweł; Kozłowski, Kazimierz; Jamsheer, Aleksander

The First Report of Biallelic Missense Mutations in the SFRP4 Gene Causing Pyle Disease in Two Siblings

Frontiers in Genetics, 11 , 2020.

Links - BibTeX - Tagi:

Casanova, Jean-Laurent; Su, Helen C; Abel, Laurent; Aiuti, Alessandro; Almuhsen, Saleh; Arias, Andres Augusto; Bastard, Paul; Biggs, Catherine; Bogunovic, Dusan; Boisson, Bertrand; Boisson-Dupuis, Stephanie; Bolze, Alexandre; Bondarenko, Anastasia; Bousfiha, Aziz; Brodin, Petter; Bustamante, Jacinta; Butte, Manish; Casari, Giorgio; Ciancanelli, Michael; Cobat, Aurelie; Condino-Neto, Antonio; Cooper, Megan; Dalgard, Clifton; Espinosa, Sara; Feldman, Hagit; Fellay, Jacques; Franco, Jose Luis; Hagin, David; Itan, Yuval; Jouanguy, Emmanuelle; Lucas, Carrie; Mansouri, Davood; Meyts, Isabelle; Milner, Joshua; Mogensen, Trine; Morio, Tomohiro; Ng, Lisa; Notarangelo, Luigi D; Okada, Satoshi; Ozcelik, Tayfun; Palacin, Pere Soler; Planas, Anna; Prando, Carolina; Puel, Anne; Pujol, Aurora; Redin, Claire; Renia, Laurent; Gallego, Jose Carlos Rodriguez; Quintana-Murci, Lluis; Sancho-Shimizu, Vanessa; Sankaran, Vijay; Seppanen, Mikko R J; Shahrooei, Mohammad; Snow, Andrew; Spaan, Andras; Tangye, Stuart; Tur, Jordi Perez; Turvey, Stuart; Vinh, Donald C; von Bernuth, Horst; Wang, Xiaochuan; Zawadzki, Paweł; Zhang, Qian; Zhang, Shenying

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Cell, 181 (6), pp. 1194–1199, 2020.

Links - BibTeX - Tagi:

2019

Stracy, Mathew; Wollman, Adam JM; Kaja, Elżbieta; Gapiński, Jacek; Lee, Ji-Eun; Leek, Victoria A; McKie, Shannon J; Mitchenall, Lesley A; Maxwell, Anthony; Sherratt, David J; Leake, Mark C; Zawadzki, Paweł

Single-molecule imaging of DNA gyrase activity in living Escherichia coli

Nucleic Acids Research, 47 (1), pp. 210-220, 2019.

Links - BibTeX - Tagi:

2018

Zawadzka, Katarzyna; Zawadzki, Paweł; Baker, Rachel; Rajasekar, Karthik V; Wagner, Florence; Sherratt, David J; Arciszewska, Lidia K

MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

eLife, 7 , 2018.

Abstract - Links - BibTeX - Tagi:

2016

Stracy, Mathew; Jaciuk, Marcin; Uphoff, Stephan; Kapanidis, Achillefs N; Nowotny, Marcin; Sherratt, David J; Zawadzki, Paweł

Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli

Nature Communications, 7 , pp. 12568, 2016, ISSN: 2041-1723.

Abstract - Links - BibTeX - Tagi:

2012

Pinkney, J N M; Zawadzki, Paweł; Mazuryk, Jarosław; Arciszewska, L K; Sherratt, D J; Kapanidis, A N

Capturing reaction paths and intermediates in Cre-loxP recombination using single-molecule fluorescence

Proceedings of the National Academy of Sciences, 109 (51), pp. 20871–20876, 2012, ISSN: 0027-8424.

Abstract - Links - BibTeX - Tagi:

@article{Pinkney2012,
title = {Capturing reaction paths and intermediates in Cre-loxP recombination using single-molecule fluorescence},
author = {J N M Pinkney and Paweł Zawadzki and Jarosław Mazuryk and L K Arciszewska and D J Sherratt and A N Kapanidis},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23184986 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3529024 http://www.pnas.org/cgi/doi/10.1073/pnas.1211922109},
doi = {10.1073/pnas.1211922109},
issn = {0027-8424},
year = {2012},
date = {2012-12-01},
journal = {Proceedings of the National Academy of Sciences},
volume = {109},
number = {51},
pages = {20871--20876},
abstract = {Site-specific recombination plays key roles in microbe biology and is exploited extensively to manipulate the genomes of higher organisms. Cre is a well studied site-specific recombinase, responsible for establishment and maintenance of the P1 bacteriophage genome in bacteria. During recombination, Cre forms a synaptic complex between two 34-bp DNA sequences called loxP after which a pair of strand exchanges forms a Holliday junction (HJ) intermediate; HJ isomerization then allows a second pair of strand exchanges and thus formation of the final recombinant product. Despite extensive work on the Cre-loxP system, many of its mechanisms have remained unclear, mainly due to the transient nature of complexes formed and the ensemble averaging inherent to most biochemical work. Here, we address these limitations by introducing tethered fluorophore motion (TFM), a method that monitors large-scale DNA motions through reports of the diffusional freedom of a single fluorophore. We combine TFM with Foerster resonance energy transfer (FRET) and simultaneously observe both large- and small-scale conformational changes within single DNA molecules. Using TFM-FRET, we observed individual recombination reactions in real time and analyzed their kinetics. Recombination was initiated predominantly by exchange of the "bottom-strands" of the DNA substrate. In productive complexes we used FRET distributions to infer rapid isomerization of the HJ intermediates and that a rate-limiting step occurs after this isomerization. We also observed two nonproductive synaptic complexes, one of which was structurally distinct from conformations in crystals. After recombination, the product synaptic complex was extremely stable and refractory to subsequent rounds of recombination.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

2010

Zawadzki, Paweł; Ślósarek, Genowefa; Boryski, Jerzy; Wojtaszek, Przemysław

A fluorescence correlation spectroscopy study of ligand interaction with cytokinin-specific binding protein from mung bean

Biological Chemistry, 391 (1), pp. 43–53, 2010, ISSN: 1437-4315.

Abstract - Links - BibTeX - Tagi: