prof. UAM dr hab. Jacek Gapiński
Zainteresowania naukowe
- Struktura i dynamika miękkiej materii
- Optyczne metody badania dyfuzji w ośrodkach prostych i złożonych
- Egzotyczna mikroskopia optyczna (LSM, TIRF, FLIM, up-conversion)
Wykształcenie
- III Liceum Ogólnokształcące w Poznaniu, 1985
- magister fizyki, Wydział Matematyki i Fizyki UAM w Poznaniu, 1990
- doktor fizyki, Wydział Matematyki i Fizyki UAM w Poznaniu, 1994
- habilitacja z fizyki, Wydział Fizyki UAM w Poznaniu, 2010
Inne informacje
Zatrudnienie: 1988: pomoc techniczna w ZBM; 1990: asystent w ZBM; 1994: adiunkt w ZBM; 2012: prof. UAM w ZBM
Staże zagraniczne:
- ok. 2 lat w postaci 1-4 miesięcznych wyjazdów do Max-Planck-Institut fuer Polymerforschung w Moguncji, Niemcy (grupa prof. E. W. Fischera)
- ok. roku w postaci 1-3 miesięcznych wyjazdów do Forschungszentrum Juelich, Niemcy (grupa prof. J. Dhonta)
- ok. roku w postaci 1-3 miesięcznych wyjazdów do Research Center of Crete, Grecja (prof. G. Fytas, D. Vlassopoulos)
- 3 wyjazdy 30-dniowe do Stanford University (Wydział Chemii, prof. Robert Pecora)
Wypromowani doktorzy:
- Tomasz Śliwa (2015) „Badania nad strukturą i właściwościami polimerów zbudowanych z poli(N-izopropyloakryloamidu) i ich potencjalne zastosowanie w medycynie”
Nagrody i wyróżnienia:
- Liczne Nagrody Rektora UAM
Przynależność do Towarzystw Naukowych:
- Polskie Towarzystwo Fizyczne, Polskie Towarzystwo Biofizyczne
2021
Litowczenko, Jagoda; Gapiński, Jacek; Markiewicz, Roksana; Woźniak, Anna; Wychowaniec, Jacek K; Peplińska, Barbara; Jurga, Stefan; Patkowski, Adam
Synthesis, characterization and in vitro cytotoxicity studies of poly-N-isopropyl acrylamide gel nanoparticles and films Journal Article
In: Materials Science and Engineering: C, vol. 118, pp. 111507, 2021, ISSN: 0928-4931.
Abstract | Links | BibTeX | Tagi: Cell cytotoxicity, Dynamic light scattering, Films, Hydrogels, Poly-N-isopropyl acrylamide (pNIPAM), Swelling and deswelling properties
@article{LITOWCZENKO2021111507,
title = {Synthesis, characterization and in vitro cytotoxicity studies of poly-N-isopropyl acrylamide gel nanoparticles and films},
author = {Jagoda Litowczenko and Jacek Gapiński and Roksana Markiewicz and Anna Woźniak and Jacek K Wychowaniec and Barbara Peplińska and Stefan Jurga and Adam Patkowski},
url = {http://www.sciencedirect.com/science/article/pii/S0928493120334251},
doi = {https://doi.org/10.1016/j.msec.2020.111507},
issn = {0928-4931},
year = {2021},
date = {2021-01-01},
journal = {Materials Science and Engineering: C},
volume = {118},
pages = {111507},
abstract = {In this work, we show synthesis that leads to thermoreponsive poly-N-isopropyl acrylamide (pNIPAM) nanogels with sizes below 100 nm, irrespectively of the surfactant to crosslinker ratio. We also show that in many environments the temperature induced pNIPAM collapse at Lower Critical Solution Temperature (LCST) of 32.5 °C is accompanied by gel nanoparticles' aggregation. Thus, the proper information on the nanoparticle (NP) structure and deswelling can be obtained only if the routinely measured hydrodynamic radius is supplemented by information on the molecular weight, which can be obtained from the intensity of scattered light. We measured the dynamics and reversibility of the deswelling and subsequent aggregation processes. Furthermore, we show that the highly concentrated pNIPAM gel NPs reversibly form bulk hydrogel networks of varied interconnected porous structure. We show, that in case of drying pNIPAM gel NPs above the LCST, it is possible to obtain films with 20-fold increase in storage modulus (G′) compared to hydrogel networks measured at room temperature. They exhibit temperature hysteresis behavior around LCST of 32.5 °C similar to pNIPAM films. Finally, we show that these hydrogel films, lead to extended proliferation of cells across three different types: fibroblast, endothelial and cancer cells. Additionally, none of the films exhibited any cytotoxic effects. Our study brings new insights into physicochemical characterization of pNIPAM gel NPs and networks behavior in realistic conditions of in vitro measurements, especially by means of dynamic light scattering as well as final unique properties of both gel NPs and formed porous films for possible tissue engineering applications.},
keywords = {Cell cytotoxicity, Dynamic light scattering, Films, Hydrogels, Poly-N-isopropyl acrylamide (pNIPAM), Swelling and deswelling properties},
pubstate = {published},
tppubtype = {article}
}